NFL MNF Week 16 Most Bet 1st TD: 49ers vs Colts

Here are the most bet NFL Week 16 Monday Night Football first touchdown bets from BetMGM insights, featuring the San Francisco 49ers and Indianapolis Colts.

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Christian McCaffrey (SF) +335

Bettors often start with the safest option, and McCaffrey’s early-game usage makes him a popular pick to open the scoring.

Jonathan Taylor (IND) +325

Taylor’s power running and early touches make him a strong candidate to score first, especially if the Colts script an opening drive around the run game.

George Kittle (SF) +750

At longer odds, Kittle attracts bettors looking for a high-impact play early. One busted coverage or play-action strike could cash this quickly.

Tyler Warren (IND) +1500

This is a true long-shot play, but bettors are chasing value on a player who could be featured in a scripted opening red-zone package.

Jauan Jennings (SF) +900

Jennings offers appealing odds for bettors who believe San Francisco may strike through the air early, especially off play-action.

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